Open Access Dataset and Data Repositories

With 2,832 participants the ACTIVE Study is the largest study on cognitive training ever performed. Funded by the National Institutes of Health and led by researchers at the University of Alabama at Birmingham the National Institute on Aging the Indiana University School of Medicine Penn State University and others the ACTIVE study proves that healthy older adults can make significant cognitive improvements with appropriate cognitive training and practice. It also demonstrates that Posit Science training drives improvements that are significantly better than other types of cognitive exercise.

Investigators used association testing on single variants (MAF > 0.5%) and aggregates of rare (MAF < 1%) coding and non-coding variants with the R3 WGS data from the Alzheimer’s Disease Sequencing Project (ADSP) to uncover common and rare genetic variation that may have been missed by traditional genotyping methods within the pooled samples and population subgroups (Lee et al., 2023; DOI: 10.1101/2023.09.01.23294953).

The study examined pooled samples, (N cases=6,519 and N control=6,852) and within the three subgroups: African Americans (AA, N cases=1,137 and N control=1,707), Hispanics (HIS, N cases=1,021 and N control=1,988), and Non-Hispanic White (NHW, N cases=4,230 and N control=3,109) defined by reported race and ethnicity.

Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in ancestry groups of predominantly non-European ancestral backgrounds in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry collection of GWAS datasets in the Alzheimer’s Disease Genetics Consortium (ADGC) to test for novel shared and population-specific late-onset Alzheimer’s Disease (LOAD) susceptibility loci. We evaluated the underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6,728 African American (AFA), 8,899 Hispanic (HIS), and 3,232 East Asian individuals (EAS), performing within ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis. All Cases met either NINCDS-ADRDA Working Group (McKhann et al 1984; PMID: 6610841) or NIA-AA Working Group (PMID: 21514250) criteria for clinical AD diagnoses or have autopsy-confirmed disease and have diagnosis after age 60 years. All non-cases/controls were cognitively intact, with an MMSE>28 and at least 60 years of age at their last exam; or were deceased after age 60 and free of cognitive complaint prior to death or have autopsy-confirmation of limited AD pathology. Data available here include ancestry-specific GWAS meta-analysis summary statistics (NHW, AFA, HIS, EAS) and cross-ancestry GWAS meta-analysis summary statistics (NHW+AFA+HIS+EAS).

Alzheimer’s Disease (AD) GWAS was conducted in 9,168 subjects (2,903 cases; 6,265 controls) of African ancestry.

Participants were diagnosed for AD according to the National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association criteria. Age at onset for AD patients and age at examination or death for healthy controls was available for most datasets. When not available, other information was used instead, such as age at diagnosis or age at ascertainment. To restrict the analyses to cases with late-onset AD, individuals with age <60 years at symptom onset, last examination, or death were excluded.

Genome-wide single-variant association analyses of common and rare variants were performed individually on 17 independent datasets using SNPTEST. One of these datasets include 705 individuals from West Africa (sampled from Ibadan, Nigeria).

Each dataset was independently phased and imputed to the African Genome Resource (AGR) reference panel.

Age, sex, and population stratification (as determined by the first three principal components (PCs) calculated individually on each dataset) were entered as covariates in Model 1; APOEe4 allele dosage (coded as 0,1,2) was entered as an additional covariate in Model 2. Logistic regression was used for case-control datasets and generalized estimating equations (GEE) as implemented in GWAF were used for family-based datasets (i.e., MIRAGE). Associations with extreme beta coefficients (|β| > 5) were filtered out. Within-study results were subsequently meta-analyzed with METAL employing an inverse-variance based model with genomic control.

This dataset contains the sex‑stratified and sex‑interaction summary statistics for memory performance and memory‑decline slopes published in Eissman and colleagues, 2022 (Brain, PubMed Identifier: 35552371). Cognitive and pathology data were harmonized across two datasets with autopsy‑based measures of amyloid pathology—the Religious Orders Study/Memory and Aging Project and the Adult Changes in Thought study—and two datasets with amyloid positron‑emission‑tomography imaging—the Anti‑Amyloid Treatment in Asymptomatic Alzheimer’s Disease study and the Alzheimer’s Disease Neuroimaging Initiative.

Resilience phenotypes were calculated using a latent‑variable modeling approach that estimated better‑than‑expected cognitive performance for a given level of amyloid pathology. The cognitive‑resilience phenotype incorporated amyloid burden, age, and sex. The global‑cognitive‑resilience phenotype further included years of education in the residual‑cognition model.

Genotype data in each study underwent standard quality‑control procedures and were imputed to the Trans‑Omics for Precision Medicine reference panel (genome build 38). Genome‑wide association studies of both resilience phenotypes were conducted using the full sample, as well as in a subset restricted to individuals who were cognitively normal, to assess resilience during the preclinical stage of Alzheimer’s disease.

The American Time Use Survey (ATUS) provides nationally representative estimates of how where and with whom Americans spend their time and is the only federal survey providing data on the full range of nonmarket activities from childcare to volunteering. ATUS data files are used by researchers to study a broad range of issues the data files include information collected from over 136000 interviews conducted from 2003 to 2012.

The Natality online databases report counts of live births occurring within the United States to U.S. residents. Counts can be obtained by a variety of demographic characteristics such as state and county of residence mothers race and mothers age and health and medical items such as tobacco use method of delivery and congenital anomalies. The data are derived from birth certificates. For more information refer to Natality data description.

National-level mortality data help track the characteristics of those who have died monitor and make decisions about public health challenges determine life expectancy and compare death trends with other countries.

The National Center for Health Statistics (NCHS) Data Linkage Program links NCHS survey data with data from the Department of Housing and Urban Development (HUD). Linking NCHS data with HUD data files enables researchers to study the relationship between housing and health. Find links to reports and resources for linked HUD data.

The Longitudinal Studies of Aging (LSOAs) is a collaborative project of National Center for Health Statistics (NCHS) and the National Institute on Aging (NIA). It is a multicohort study of persons 70 years of age and over designed primarily to measure changes in the health, functional status, living arrangements, and health services utilization of two cohorts of Americans as they move into and through the oldest ages.

The project is comprised of four surveys:

The 1994-2000 Second Longitudinal Study of Aging (LSOA II)

The 1984 Supplement on Aging (SOA)

The 1984-1990 Longitudinal Study of Aging (LSOA)

The 1994 Second Supplement on Aging (SOA II)

The National Death Index (NDI) connects public health and medical researchers with U.S. death records.

NDI links researchers’ data to death certificate information for their study subjects.

NDI fees vary based on the number of study subjects, the type of search requested, and the length of time to be searched.

The Mortality Followback Survey Program begun in the 1960s by the National Center for Health Statistics (NCHS) uses a sample of United States residents who die in a given year to supplement the death certificate with information from the next of kin or another person familiar with the decedents life history. This information sometimes enhanced by administrative records provides a unique opportunity to study the etiology of disease demographic trends in mortality and other health issues. The first mortality followback survey conducted in 1961 featured information on hospital and institutional care in the last year of life. Information from the 1962-63 survey permitted an extensive analysis of socioeconomic differentials in mortality. Data from the 1964-65 survey included expenditures for health care during the last year of life sources of payment and health insurance coverage of decedents. The 1966-68 survey provided information on the link between smoking and cancer mortality. In 1986 the survey provided data on co-morbid conditions disabilities alcohol use and access to health care services.

The National Ambulatory Medical Care Survey (NAMCS) is designed to meet the need for objective reliable information about the provision and use of ambulatory medical care services in the United States. Findings are based on a sample of visits to nonfederally employed office-based physicians who are primarily engaged in direct patient care and starting in 2006 a separate sample of visits to community health centers.
The National Hospital Ambulatory Medical Care Survey (NHAMCS) is designed to collect data on the utilization and provision of ambulatory care services in hospital emergency and outpatient departments and ambulatory surgery locations. Findings are based on a national sample of visits to the emergency departments outpatient departments and ambulatory surgery locations of noninstitutional general and short-stay hospitals.

The National Health Interview Survey (NHIS) has monitored the health of the nation since 1957. NHIS data on a broad range of health topics are collected through personal household interviews. Survey results have been instrumental in providing data to track health status health care access and progress toward achieving national health objectives.

The National Health Care Surveys are a family of surveys that provide information about—

• Organizations and providers that deliver health care
• The healthcare services they provide
• The patients they serve across diverse healthcare settings

Researchers, policymakers, and health professionals can use data from our surveys to understand providers, patients, and management and delivery of patient care in the United States.

• National Ambulatory Medical Care Survey
• National Electronic Health Records Survey
• National Hospital Ambulatory Medical Care Survey
• National Hospital Care Survey
• National Post-acute and Long-term Care Study

Our surveys are unique because they are—

From a wide range of healthcare settings, with data and analysis that show the variety of ways health care is provided

Nationally representative, accurately reflecting the diversity of health providers, services, patients, and facilities across the United States

Provider-based, collecting data directly from the professionals who deliver healthcare services and operate healthcare facilities

From a wide range of healthcare settings, with data and analysis that show the variety of ways health care

The National Hospital Discharge Survey (NHDS) which was conducted annually from 1965-2010 was a national probability survey designed to meet the need for information on characteristics of inpatients discharged from non-Federal short-stay hospitals in the United States. Data from the NHDS are available annually and are used to examine important topics of interest in public health and for a variety of activities by governmental scientific academic and commercial institutions.

The National Immunization Surveys (NIS) are a group of telephone surveys sponsored and conducted by CDCs National Center for Immunization and Respiratory Diseases (NCIRD). Since 2018 the National Immunization Surveys have used a single frame survey design that includes calling cell phone numbers for household interviews with parents or guardians. If the parent or guardian provides consent and contact information a questionnaire is mailed to childrens vaccination providers. Learn more

The first national probability survey of nursing assistants working in nursing homes in the United States.

The National Nursing Home Survey (NNHS) is a series of nationally representative sample surveys of United States nursing homes their services their staff and their residents. The NNHS was first conducted in 1973-1974 and repeated in 1977 1985 1995 1997 1999 and most recently in 2004. Although each of these surveys emphasized different topics they all provided some common basic information about nursing homes their residents and their staff. All nursing homes included in this survey had at least three beds and were either certified (by Medicare or Medicaid) or had a state license to operate as a nursing home.

The National Survey of Ambulatory Surgery (NSAS) is the only national study of ambulatory surgical care in hospital-based and freestanding ambulatory surgery centers (ASCs). The NSAS was first conducted from 1994 to 1996 but it was discontinued due to lack of resources. The NSAS was conducted again in 2006. Efforts are now underway to include ambulatory surgery centers in the National Hospital Ambulatory Medical Care Survey (NHAMCS). The NHAMCS website provides more information on the efforts. More information

NCHS has linked various surveys with Medicare enrollment and claims records collected from the Centers for Medicare Medicaid Services (CMS). Linkage of the NCHS survey participants with the CMS Medicare data provides the opportunity to study changes in health status health care utilization and expenditures among the elderly U.S. population and persons receiving Medicare disability benefits. Medicare enrollment and claims data are available for those NCHS respondents who agreed to provide personal identification data to NCHS and for whom NCHS was able to match with Medicare administrative records. CMS provided NCHS with Medicare benefit claims data for 1999 through 2013 for all successfully matched NCHS survey participants. For certain NCHS surveys the Medicare administrative files include data from before and after the survey year of interview. CMS also provided to NCHS Medicare Part D data for 2006-2013.

NCHS has linked various surveys with End Stage Renal Disease (ESRD) data obtained from the United States Renal Data System (USRDS). Linkage of the NCHS survey participants with the USRDS ESRD data provides the opportunity to study changes in health status and health care utilization among patients diagnosed with ESRD. ESRD data are available for those NCHS respondents who agreed to provide personal identification data to NCHS and for whom NCHS was able to match with USRDS administrative records. Available ESRD patient data covers service from 1974 through 2008.

The Second Longitudinal Study of Aging (LSOA II) is a collaborative effort of the National Center for Health Statistics (NCHS) and the National Institute on AgingExternal (NIA). The Second Supplement on Aging (SOA II) conducted in conjunction with the 1994 National Health Interview Survey (NHIS) served as the baseline for the study. The LSOA II is a prospective study with a nationally representative sample comprised of 9447 civilian noninstitutionalized persons 70 years of age and over at the time of their SOA II interview. The LSOA II followed this cohort of older persons through two followup interviews conducted in 1997-98 and 1999-2000. While the baseline interview was administered face-to-face in the home by U.S. Census Bureau interviewers followup interviews were administered using Computer Assisted Telephone Interviews (CATI) by the National Opinion Research Center at the University of Chicago. Plans are to augment the interview data by linkage to Medicare recordsExternal the National Death Index and multiple cause-of-death records.

National Centre for Health Statistics has linked various surveys with the Old Age Survivors and Disability Insurance (OASDI) and Supplemental Security Income (SSI) benefit records collected from the Social Security Administration (SSA). Linkage of the NCHS survey participants with the SSA-OASDI and SSA-SSI data provides the opportunity to further study the elderly and disabled U.S. population.

The China Health and Retirement Longitudinal Study (CHARLS) aims to collect a high quality nationally representative sample of Chinese residents ages 45 and older to serve the needs of scientific research on the elderly. The baseline national wave of CHARLS is being fielded in 2011and includes about 10000 households and 17500 individuals in 150 counties/districts and 450 villages/resident committees. The individuals will be followed up every two years. All data will be made public one year after the end of data collection.

The Chinese Longitudinal Healthy Longevity Survey (CLHLS) began in 1998 and has been funded by a variety of sources over the course of the project. These sources include National Institute on Aging/National Institutes of Health grants awarded to Duke University, Chinese support, the United Nations Population Fund (UNFPA) and the China Social Sciences Foundation, the Max Planck Institute for Demographic Research, and the China Natural Sciences Foundation and the Hong Kong Research Grants Council (RGC).

The CLHLS provides information on health status and quality of life of the elderly aged 65 and older in 22 provinces of China. The study was initially conducted to shed light on the determinants of healthy human longevity and oldest-old mortality. Data were collected on a larger percentage of the oldest population, including centenarian and nonagenarian, than had previously been studied, with follow-up waves taking place after two to three years. With the oldest-old sub-population growing faster than any other age group, the CLHLS sought to investigate the demographic, socioeconomic psychological and health status of the oldest-old. The goal of the CLHLS is to determine which factors, out of a large set of social, behavioral, biological, and environmental factors, play an important role in healthy longevity.

The goal of the project is to identify recurrent genetic alterations (mutations deletions amplifications rearrangements) and/or gene expression signatures. National Cancer Institute (NCI) utilized whole genome sequencing and/or whole exome sequencing in conjunction with transcriptome sequencing. The samples were processed and submitted for genomic characterization using pipelines and procedures established within The Cancer Genome Analysis (TCGA) project. More information

The Cohorts for Heart and Aging Research in Genomic Epidemiology investigators conducted single‑variant association analyses of common genetic variants, rare‑variant aggregate analyses, and targeted association analyses in sub‑populations using the Release 1 Whole‑Genome Sequencing data from the Alzheimer’s Disease Sequencing Project. The goal was to identify causal and rare genetic variants linked to genomic regions previously highlighted by the Alzheimer’s Disease genome‑wide association studies (Wang et al., 2024; DOI: 10.1002/alz.13705).

Individuals were included if they were genetically unique, passed all quality‑control procedures, and had either a diagnosis of Alzheimer’s disease or were classified as controls. This resulted in a combined study population of 2,184 Alzheimer’s disease cases and 2,383 controls.

The Colorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife) aims are to: conduct a genetically sensitive study of individual differences in behavioral and cognitive change at the cusp of middle adulthood, in participants from the Colorado Adoption Project (CAP) and Longitudinal Twin Study (LTS) studied almost yearly from birth to early adulthood; map individual differences in growth and maintenance of cognitive abilities; evaluate and trace measured physical factors and health behaviors, biochemical markers and measured genetic pathways important to sustaining cognitive performance; and track measured environmental factors that might decrease, sustain or boost cognitive performance. (R01 AG046938 co-PI’s: Reynolds (contact), Wadsworth).

This data release includes from 1,062 respondents from the Longitudinal Twin Study (LTS) subsample who provided consent to share data and who completed cognitive assessments at one or more of the following assessments (early infancy (7 to 9 months), year 1-2 (14, 20, 24 months), year 3, year 7, year 16, or CATSLife wave 1 (mean year 29). All variables analyzed in the following paper are included [PMCID: PMC12130889], including polygenic scores for subjects who were genotyped.

The Relating Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile study is the Multiple Myeloma Research Foundation (MMRF)s landmark personalized medicine initiative. CoMMpass is a longitudinal observation study of around 1000 newly diagnosed myeloma patients receiving various standard approved treatments. The MMRFs vision is to track the treatment and results for each CoMMpass patient so that someday the information can be used to guide decisions for newly diagnosed patients. CoMMpass checked on patients every 6 months for 8 years collecting tissue samples genetic information quality of life and various disease and clinical outcomes. The study has produced one of the largest genomic and clinical datasets of a single disease. More information

This survey is one component of the evaluation of the Community Partnerships for Older Adults (CPOA) Program an initiative of the Robert Wood Johnson Foundation aimed at promoting improvements in the organization and delivery of long-term care and supportive services for older adults through local public-private community partnerships. The survey interviewed a representative sample of older adults aged 50 and over in 13 communities that were awarded development grants by the program. Designed to obtain baseline data about each communitys population and to provide information to target the CPOAs activities in the most effective way the survey interviewed respondents about supportive and long-term care services for older adults in their communities including the availability use of and quality of the services and sources of information about them. Respondents were asked if they expected to stay in their community if their homes needed repairs or modifications to improve their ability to live in them how important it was to be able to live in their own home as they grew older the age at which they thought they would need help to continue living in their own home and the age at which they thought they could no longer live at home because of health problems. The survey also collected information on health status problems with activities of everyday life health insurance coverage and long-term care insurance hospital stays living arrangements social activities support from family and friends access to transportation and demographic characteristics.

The Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy Study (CALERIE) was funded by the National Institute on Aging and tested the hypothesis that two years of sustained 25% caloric restriction reduce resting metabolic rate and core temperature indicative of metabolic adaptation. Secondary hypotheses included proposed favorable adaptations reflecting primary aging and leading to improvements in aging biomarkers and chronic diseases of aging.

A harmonized collection of the core data pertaining to COVID-19 reported cases by geography in a format prepared for analysis. New COVID-19 data added twice daily. More information

The Costa Rican Longevity and Healthy Aging Study (CRELES or Costa Rica Estudio de Longevidad y Envejecimiento Saludable) is a set of nationally representative longitudinal surveys of health and lifecourse experiences of older Costa Ricans. CRELES was conducted by the University of Costa Ricas Centro Centroamericano de Poblacin and Instituto de Investigaciones en Salud in collaboration with the University of California at Berkeley. Baseline CRELES household interviews were conducted primarily in 2005 with 2-year follow-up interviews in 2007 and 2009. The sample was drawn from Costa Rican residents in the 2000 population census who were born in 1945 or before with an over-sample of the oldest-old (ages 95 and over). The main study objective was to determine the length and quality of life and its contributing factors in the elderly of Costa Rica. The series includes data on a broad range of topics including self-reported physical health psychological health living conditions health behaviors health care utilization social support and socioeconomic status. The data also include measured (biomarkers) and observed heath indicators as well as mortality information provided by surviving family members. More information

The ENabling Reduction of low-Grade Inflammation in SEniors (ENRGISE) pilot study was conducted to test whether omega-3 fish oil and the angiotensin receptor blocker losartan alone or in combination can reduce inflammation and improve walking speed in older adults with mobility impairment.

The English Longitudinal Study of Ageing (ELSA) is a longitudinal study that collects multidisciplinary data from a representative sample of the English population aged 50 and older. The survey data are designed to be used for the investigation of a broad set of topics relevant to understanding the ageing process. Both objective and subjective data are collected covering themes such as: health trajectories disability and healthy life expectancy the determinants of economic position in older age the links between economic position physical health cognition and mental health the nature and timing of retirement and post-retirement labour market activity household and family structure social networks and social supports patterns determinants and consequences of social civic and cultural participation and predictors of well-being. ELSA is led by Professor Sir Michael Marmot and is jointly run by teams at University College London (UCL) the Institute for Fiscal Studies (IFS) National Centre for Social Research and the University of Manchester.

The 2008 crisis has tended to widen disparities in employment rates and in 2013 rates were 11 percentage points higher in more developed regions than in less developed ones (72 and 61). Under the Europe 2020 strategy Member States have set national targets for the employment rate which are broadly consistent with the 75 overall target being achieved by 2020. These vary from 62.9 in Malta to 80 in Denmark and Sweden.

The Eurobarometer survey on Active Ageing has been commissioned by the European Commission s Directorate General for the Employment Social Affairs and Inclusion to understand citizens views and attitudes towards older people the contribution of older people in the workplace and society and how to best promote an active role of older people in society. The main themes addressed in this report are: – Overall perceptions of age and older people perceptions of and attitudes towards older people the potential role for older people in society and the impact of the ageing population in the future – Older people in the workplace attitudes towards older people in the workplace and potential barriers to continuing work – Retirement and pensions attitudes towards the official retirement age and pension payments and whether any changes are appropriate – Voluntary work and support for older people establishing the level of personal participation in voluntary work and care of older people – Age friendly environment identifying the countries/areas best adapted to the needs of older people and how improvements can be made in those most poorly adapted.

This Eurobarometer survey on discrimination was commissioned to find out more about peoples attitudes towards discrimination. Women and men in all fifteen member countries were asked about discrimination they may have experienced or seen at work in education in seeking housing or as a customer of retail or other services. They were also asked about their attitudes towards discrimination. The questionnaire included questions on peoples perceptions of discrimination on the five grounds covered by the Community Action Programme against Discrimination: racial or ethnic origin religion or beliefs disability (physical disability learning difficulties or mental illness) age and sexual orientation.

In the period from 13 to 29 June 2006 the second wave of the research in survey on consumer rights issues was conducted in Slovakia in Slovenia in Czech Republic. This survey was carried out using a representative sample of 1143 citizens of the Slovak Republic aged 15 years or older who answered questions on the following themes: – Survey on awareness and evaluation of the consumers rights campaign – Consumer rights in the media – Awareness and use of services provided by consumer protection organisations – Awareness of consumer rights The objective of the present study was to measure the initial impact of a European Union consumer rights information campaign which began in Slovakia in May 2006 and will run until the end of the year.

In this summary we present the findings from a survey about discrimination and inequality in Europe that was carried out by TNS Opinion Social on behalf of the European Commission DG Employment Social Affairs and Equal Opportunities in the twenty-five Member States of the European Union and in the two acceding countries between 7 June and 12 July 2006. In this summary the six legally prohibited forms of discrimination in the EU are examined: discrimination on the basis of sex ethnic origin religion or beliefs age disability and sexual orientation. Abbreviations used in this summary correspond to: EU25 European Union – 25 Member States at the time of the survey and prior to the accession of Bulgaria and Romania EU15 European Union – 15 Member States before the most recent enlargement (1st May 2004) DK Dont know Readers are reminded that survey results are estimations the accuracy of which rests upon the sample size and upon the observed percentages.

The European anti-discrimination legislation is one of the most extensive in the world. Even so 16 of Europeans reported experiencing discrimination in 2009 with age being the most common reason. However it is discrimination based on ethnic origin which is most widely perceived. The economic crisis has lowered confidence that governments will promote equality and increased the belief that discrimination will rise. However Europeans increasingly believe that enough is being done to combat discrimination. Despite this only a third know their rights concerning discrimination or harassment. In the report the six legally prohibited grounds of discrimination in the EU are examined: 1. Gender 2. Ethnic origin 3. Religion or beliefs 4. Age 5. Disability 6. Sexual orientation.

This survey looks into attitudes and perceptions of Europeans towards discrimination based on different grounds (gender ethnic origin religion or beliefs age disability sexual orientation and gender identity). As the last Eurobarometer on this topic from 2009 this survey also includes several questions on the impact of the crisis on the implementation of anti-discrimination policies and efforts. New questions have been added to cover important or emerging topics such as the situation of the Roma in Europe discrimination outside the workplace or the links between discrimination and accessibility. Perceptions on discrimination against transsexual and transgender persons are also explored for the first time. The report examines the following grounds of discrimination: 1. Gender 2. Ethnic origin 3. Religion or beliefs 4. Age (divided into two subcategories: age over 55 and age under 30) 5. Disability 6. Sexual orientation 7. Gender identity (being transsexual or transgender) The report is structured as follows: – Setting the context including whether citizens think of themselves as belonging to a minority group and the diversity of their social circles – Perceptions of discrimination covering attitudes to different groups and the perceived extent of discrimination in Europe in general and outside working life – A detailed analysis of discrimination on individual grounds – Measurements of discrimination in Europe whether directly experienced by Europeans or as third-party evidence – Knowledge of ones rights as a potential victim of discrimination – Assessments of national efforts made to combat discrimination and the impact of the economic crisis on equality policies – Views on equal opportunities in employment including an examination of the effect of the economic crisis on the perceived extent of discrimination – The case of the Roma.

As the last Eurobarometer on this topic in 2012 the survey looks into attitudes and perceptions of Europeans towards discrimination based on different grounds (gender ethnic origin religion or beliefs age disability sexual orientation and gender identity) and citizens opinions on different policy measures to combat discrimination. For the first time the survey explores the social acceptance of specific groups belonging to ethnic and religious minorities. Also for the first the survey is looking into social acceptance and citizens views on the rights of lesbian gay bisexual and transgender persons.

The survey focusses on persons perceptions attitudes and opinions of discrimination based on ethnic origin skin colour sexual orientation gender age disability religion and beliefs. It shows that compared to 2015 fewer EU citizens now perceive discrimination as being widespread in their country. However perceptions opinions and attitudes still vary widely depending on the group discriminated against and also from country to country.

In anticipation of this Year of Equal Opportunities for All the European Commission DG Employment Social Affairs and Equal Opportunity Opportunities commissioned a survey about discrimination and inequality in Europe conducted in the summer of 2006. This current report represents a follow-up to this survey tracking how perceptions and opinion in this field have changed in the intervening year. Several new questions are also asked in the current survey for example dealing with the subject of multiple discrimination. Both surveys were carried out by TNS Opinion Social network this current one between February 18th and March 22nd 2008. In the report the six legally prohibited forms of discrimination in the EU are examined: discrimination on the basis of gender ethnic origin religion or beliefs age disability and sexual orientation.

Before analyzing the responses from Europeans it is necessary to emphasize some important points which can be drawn from this survey. It is very difficult to reach general conclusions because of the different status of the voluntary sector in different Member States. In the absence of Eurostat or other general statistics the number of Europeans undertaking voluntary work cannot be quantified with any certainty. The contribution of the voluntary sector to the GDP of the EU and its Member States is very difficult to estimate. No EU-wide statistics are available. National data are only available in a few countries. There is a broad consensus that volunteering plays an important role in society based on the values of solidarity. It contributes to citizenship especially through the fact that it is well-established at a local level and is a factor for personal fulfillment and development. 22 to 25 of Europeans are involved in voluntary work Sport and culture: the main areas for voluntary work Solidarity and humanitarian aid: the area in which the voluntary sector plays the most important role Maintaining and strengthening social cohesion the first benefit of volunteering in the EU Defining an operating framework for the voluntary sector at national or EU level: a divided response. Massive support for the creation of volunteer rescue teams in every region – Encouraging intergenerational solidarity.

In order to get a better idea of how much people know about EU employment and social policy and what they think of it the European Commissions Directorate-General for Employment Social Affairs and Equal Opportunities commissioned this Eurobarometer study which was carried out by TNS Opinion Social using a representative sample of 24815 people aged 15 or older in the 25 Member Statestwo pre-accession countries (Bulgaria and Romania) and two candidate countries (Croatia and Turkey). The study assessed how European citizens perceive the European Unions role in employment and social affairs and how aware they are of EU instruments such as the European Social Fund. It also looked at the level of public approval for measures promoting the concept of flexicurity a policy approach which combines more flexible labour markets with high levels of employment security and social protection. This approach is currently a key issue in EU policy debates. The survey also looked at the employment situation of European citizens and their own vision of the future in other words their personal expectations of finding a job or keeping the one they have in the near future. Finally the study focused on the strategies and tools promoted by the European Employment Strategy and the ESF and looked at whether European citizens considered them important for finding or keeping a job. Particular attention was paid to training and its impact on peoples integration into the labour market and how well they adapt to a changing working environment.

A Comparison of the 1992 and 1999 Eurobarometer Surveys by: ALAN WALKER Professor of Social Policy University of Sheffield Sheffield S10 2TU UK DEMOGRAPHIC CONTEXT One of the major successes of the second half of the twentieth century has been increasing longevity reflecting the improved conditions of health and welfare standards of the population within the EU. Increasing life expectancy is an indicator of social and economic development the triumph of science and public policy over many of the causes of premature death which truncated lives in earlier times. Europe can be justly proud of the fact that in the last 50 years its model of development has allowed increasing numbers of citizens to reach advanced old age and to do so in relative economic security. However extended longevity coupled with an important decline in fertility over the last 30 years has resulted in a fast transition towards a much older population that according to demographic projections will last for several decades. The trend towards population ageing is bringing about profound changes for all generations and most areas of economic and social activity. As Europe enters the twenty-first century the demographic trend towards an ageing society is becoming a highly important issue for social protection the labour market politics design and technology education and culture in short for the whole economy and all of society.

Opinion on the needs objectives expenditures and outcomes of national family policies. Expectations for the future. Role of EU.

This public opinion survey was carried out at the request of the Directorate-General Health and Consumer Protection and was managed and organised by the Public Opinion Analysis Sector of the Directorate-General Press and Communication. It was conducted in all the Member at States of the European Union between October 28 and December 8 2002 under the general coordination of the European Opinion Research Group EEIG in Brussels. The vast majority (67.8) of EU citizens aged 15 years and over considered themselves to be healthy only 5.7 perceiving themselves to be in bad or worse health. A quarter (25.3) reported chronic morbidity and a quarter (26.3) had activity restriction with 6.2 severely restricted. Low levels of sensory functional limitation were reported (1.3 near vision 3.4 far vision and 3.0 in hearing) though without the use of aids 42.1 were limited in near vision 21.1 in far vision and 4.5 in hearing. Physical functional limitations were more common with 3.6 limited in walking 500 metres even with an aid 9.6 in climbing stairs and 10.5 in lifting 5 kilos.

Rising perceptions of unfairness coupled with political social and economic challenges can undermine the solidarity cohesion and mutual understanding that are necessary for the EU to function effectively in the interest of its citizens. In this context the European Commission has conducted a Special Eurobarometer to better understand citizens views on fairness and inequality and factors influencing their perceptions. It also provides information on Europeans inter-generational social mobility. This Special Eurobarometer shows that European Union citizens believe that what happens in their life and the decisions concerning them are fair. At an individual level Europeans generally perceive life as just. Yet such feelings change substantially when fairness is assessed at country level and when specific aspects of life are concerned.

The Flash Eurobarometer Intergenerational solidarity (Flash No 269) was conducted in order to examine EU citizens opinions about: existing relations between the younger and older generations costs of an ageing population particularly in terms of pensions and elderly care the need for pension and social security reforms ways in which older people contribute to society financially and in a broader way existing possibilities for autonomous living for elderly EU citizens the provision of elderly care and support by social services the role of public authorities in promoting intergenerational solidarity.

This is the first Eurobarometer survey that asks citizens for their views in a detailed way. Its interesting findings confirm the political goals set at the European Council Summit in Lisbon and they reinforce the importance of the work that is being done at European level on lifelong learning and e-learning. The survey covers residents of all Member States as well as Iceland and Norway with the relevant country nationality and aged 15 years and over. A new sample is drawn for each Eurobarometer survey. It is representative of the population aged 15 in terms of gender age NUTS2 region and urbanisation size. The average number of people interviewed in each country was 1 000 except in Germany (2 144 interviews) the United Kingdom (1 439) Luxembourg (615) and Iceland (628). Altogether 18 227 interviews were conducted including 16 567 in the European Union. All interviews were carried out face to face (18) in peoples homes and in the appropriate national language. Up to four recalls were made. The 15 main questions were worded in a format specific to Eurobarometer surveys. Two types of questions were used: multiple-choice questions where the respondent is asked to give one or up to three answers depending on the question and a list of items for which interviewees are asked to respond to each. In all cases respondents can reply that they have no idea (coded as dont know).

The survey examines attitudes and perceptions of Europeans towards discrimination based on different grounds (gender ethnic origin religion or beliefs age disability sexual orientation and gender identity). It also includes several questions on the impact of the crisis on the implementation of anti-discrimination policies and efforts. New questions have been added to cover important or emerging topics such as the situation of the Roma in Europe discrimination outside the workplace or the links between discrimination and accessibility. Perceptions on discrimination against transsexual and transgender persons are also explored for the first time.

The project Safer and healthier work at any age occupational safety and health (OSH) in the context of an ageing workforce was initiated and financed by the European Parliament (see Official Journal of the European Communities 29.02.2012 II/230 – II/231) and was carried out by EU-OSHA by delegation from the European Commission. The aim of the European Parliament was to investigate ways of improving health and safety at work considering the challenges of an ageing workforce and to assist policy development in this area. The project carried out by the agency provides a comprehensive overview of issues related to ageing work and OSH and an analysis of policies and initiatives addressing the ageing of the workforce across Europe. The project also took account of Eurofound research on sustainable work.

The Directorate-General Employment of the European Commission commissioned a survey that examines public opinion about poverty and exclusion in the European Union. Between the 14th of February and the 18th of March 2007 TNS Opinion Social a consortium formed by TNS and EOS Gallup Europe interviewed 26466 EU citizens aged 15 and over living in the 27 European Union Member States and 1000 residents of Croatia. This report studies the following issues related to poverty and exclusion covered by the survey. First of all we focus on the perceived existence of poverty in the European Union: to what extent are Europeans themselves affected by poverty and to what extent do they see poverty in the area in which they live In this chapter we furthermore look at attitudes towards poverty: is it an inherited or acquired condition what causes poverty and why do people live in need The second part of the report focuses on one of the most extreme forms of exclusion homelessness: why do people become homeless what is the perceived risk of becoming homeless oneself and what do Europeans do to help homeless people In the final part we examine what Europeans regard necessary in order to have a decent standard of living with regards to financial means housing needs ownership of durable goods basic necessities and social integration. We also look specifically at peoples views concerning the requirements and the needs of children to live and develop well. We end the report with an examination of how peoples attitudes towards poverty relate to what they consider necessary for a decent standard of living.

A Eurobarometer survey carried out for the European Commission by INRA (Europe) – European Coordination Office in Spring 2000. This report is structured in five parts. The first section looks at the ownership and use of various information and communication technologies. The second focuses on the interest raised by these technologies and intentions to purchase them. The last three sections investigate the use of the Internet (applications and services impact on other activities and connection). The social-demographic variables used in this report are: 1) Country 2) Gender 3) Age (in four bands: 15-24 25-39 40-54 and 55 years or more) 4) Professional status (in three groups: Self-employed Employed and Not working) 5) Household income (harmonised in four bands) 6) Size of household (number of people living in household) 7) Level of education (Terminal Education Age i.e. age when finished full time education in four bands: age of 15 or less 16-19 20 years or more still studying) 8) Media use index (aggregate of three questions regarding exposure to news media radio television and newspapers- in four groups) When possible and appropriate relevant variables are considered for cross-tabulation with various social-demographic variables so as to determine the amplitude if any of inter-group differences. This report was prepared by Franois Heinderyckx PhD lecturer at the University of Brussels (ULB) Chairman of the department of Communication information and journalism.

The research team developed two self-reporting questionnaires the Older Adult Mistreatment Assessment (OAMA) Client Questionnaire and the OAMA Staff Questionnaire in order to measure for financial exploitation and psychological abuse of the elderly. The OAMA Client Questionnaire was administered to clients aged 60 years and over who had been substantiated for at least one form of elderly mistreatment within the Chicago metropolitan area. In addition a corresponding Staff Questionnaire was administered to each evaluator involved in the field test and submitted on behalf of each client in the study. In all 227 client interviews with 227 corresponding staff questionnaires were compiled between 2007 and 2008 and scales were developed for measurements of both financial exploitation and psychological abuse. Financial exploitation of the elderly was measured through variables related to theft scams coercion signs of abuse or financial entitlement by trusted friends or family members and money management difficulties. Psychological abuse of the elderly was measured through variables related to isolation disrespect exploited vulnerability shame threats and intimidation and risk factors related to the clients trusted friends or family.

The Foundation Medicine Adult Cancer Clinical Dataset (FM-AD) is a study conducted by Foundation Medicine Inc (FMI). Genomic profiling data for approximately 18000 adult patients with a diverse array of cancers was generated using FoundationeOne FMIs commercially available comprehensive genomic profiling assay. This dataset contains open Clinical and Biospecimen data. More information

Initially focused on the European population, multiple genome-wide association studies (GWAS) of complex diseases, such as type-2 diabetes (T2D), Alzheimer disease (AD), have now extended to other populations. However, to date, few ancestry-matched omics datasets have been generated or further integrated with the disease GWAS to nominate the key genes and/or molecular traits underlying the disease risk loci. In this study, we generated and integrated plasma proteomics and metabolomics with the genotype datasets of over 2,300 European (EUR) and 400 African (AFR) ancestries to identify ancestry-specific multi-omics quantitative trait loci (QTLs). In total, we mapped 954 AFR pQTLs, 2,848 EUR pQTLs, 65 AFR mQTLs, and 490 EUR mQTLs. We further applied these ancestry-stratified QTLs to the risk of metabolic disorders, (e.g. T2D, AD) to pinpoint key proteins and metabolites underlying the disease-associated genetic loci.

This dataset includes summary statistics for a genome-wide association study meta-analysis of eleven neuropathology endophenotypes. Included neuropathology endophenotypes are neuritic plaques, tau neurofibrillary tangles, cerebral amyloid angiography, amyloid-beta plaques, TDP-43 deposits, Lewy body deposits, cerebral atherosclerosis, cerebral arteriolosclerosis, gross infarcts, microinfarcts, and hippocampal sclerosis. The individual studies used in this project were National Alzheimer’s Coordinating Center (NACC), Religious Orders Study (ROS) and Rush Memory and Aging Project (MAP), and Adult Changes in Thought (ACT; n =7,804 total autopsied participants across all four studies). Each study was analyzed individually (ROS and MAP were analyzed together) with meta-analysis being subsequently performed.

Participants for this analysis were selected with whole-genome sequencing at 30x coverage from the Alzheimer’s Disease Sequencing Project dataset (ADSP, ng00067.v7). Included were 1,834 PSP cases and 128 controls from the PSP-NIH-CurePSP-Tau, PSP-CurePSP-Tau, PSP-UCLA, and AMPAD-MAYO cohorts as well as 3,008 controls from other cohorts in the ADSP dataset. For association analysis, linear mixed model implemented in R Genesis were used. Genetic relatedness matrix was obtained using KING. PCs were obtained by PC-AiR which accounts for sample relatedness. Sex and PC1-5 were adjusted in the linear mixed model. Age was not adjusted as more than half (1,159 of 1,718) of PSP cases had age missing.

The University of Michigan Health and Retirement Study (HRS) is a longitudinal panel study that surveys a representative sample of more than 26000 Americans over the age of 50 every two years. Supported by the National Institute on Aging (NIA U01AG009740) and the Social Security Administration the HRS explores the changes in labor force participation and the health transitions that individuals undergo toward the end of their work lives and in the years that follow. Since its launch in 1992 the study has collected information about income work assets pension plans health insurance disability physical health and functioning cognitive functioning and health care expenditures. Through its unique and in-depth interviews the HRS provides an invaluable and growing body of multidisciplinary data that researchers can use to address important questions about the challenges and opportunities of aging. More information HRS sister studies in other countries available through RAND Survey Meta Data Repository. The Survey Meta Data Repository is a collection of HRS-family survey data. It includes a digital library of survey questions a search engine for finding comparable questions across the surveys and a set of identically defined variables for cross-country analysis.

The Human Development Index (HDI) is a summary measure of achievements in key dimensions of human development: a long and healthy life access to knowledge and a decent standard of living. The HDI is the geometric mean of normalized indices for each of the three dimensions. The health dimension is assessed by life expectancy at birth the education dimension is measured by mean of years of education for adults aged 25 years and more and expected years of education for children and the standard of living dimension is measured by gross national income per capita. The Inequality-Adjusted Human Development Index (IHDI) adjusts the HDI for inequality in the distribution of each dimension across the population. The Gender Development Index (GDI) measures gender inequalities in achievement in three basic dimensions of human development: health measured by female and male life expectancy at birth education measured by female and male expected years of education for children and female and male mean years of education for adults ages 25 and older and command over economic resources measured by female and male estimated earned income. The Gender Inequality Index (GII) reflects gender-based disadvantage in three dimensionsreproductive health empowerment and the labour marketfor as many countries as data of reasonable quality allow. It shows the loss in potential human development due to inequality between female and male achievements in these dimensions. The Multidimensional Poverty Index (MPI) identifies multiple deprivations at the household level in education health and standard of living as indicators of poverty. It uses micro data from household surveys and unlike the IHDI all the indicators needed to construct the measure must come from the same survey.

The Human Connectome Project aims to provide an unparalleled compilation of neural data an interface to graphically navigate this data and the opportunity to achieve never before realized conclusions about the living human brain. More information

INDEPTH is a global network of HDSSs. Its 41 member centres observe the life events of millions of people in 20 LMICs in Africa Asia and Oceania. Since its inception in 1998 the network has gathered a treasure trove of robust data and is uniquely positioned both to answer the most pressing questions on health population dynamics and development and to provide policymakers and donors with evidence on the impact of interventions. This network of health and demographic surveillance systems (HDSSs) collects data from whole communities over extended time periods that reflect health and population problems in LMICs. By monitoring new health threats tracking population changes through fertility rates death rates and migration and measuring the effect of policy interventions on communities HDSSs provide information that enables policymakers to make informed decisions and to adapt their programs to changing conditions.

The Irish LongituDinal Study on Ageing (TILDA) is a study of a representative cohort of over 8500 people resident in Ireland aged 50 charting their health social and economic circumstances over a 10-year period. The second wave of data collection was completed this year. TILDA is unique amongst longitudinal studies internationally in the breadth of physical mental health and cognitive measures collected. More information

This data collection is a sociohistorical study of the ways in which three generations (Issei Nisei and Sansei) of Japanese American families adapted to social cultural educational occupational and other institutions of American life. The study examines the experience of the first immigrants to the United States (Issei) and their children (Nisei) and grandchildren (Sansei). Interviews with Issei families stressed the difficulties faced by the immigrants during their early years in the United States as well as aspects of social and cultural life. Interviews with Nisei included questions on employment attitudes toward work income education marriage social relationships discrimination and religion. Topics covered in Sansei interviews included birth order age marital status children social relationships occupation industry income education Japanese value systems marital choices influence of parents and grandparents discrimination religion political attitudes and migration. More information

In order to establish a sustainable social security system in Japan whose population is aging ahead of other developed countries it is crucial to make available micro-data on the diverse aspects of the lives of elderly people. Extensive surveys have been conducted on elderly people in many other countries and the resulting data have been utilized not only for academic and research purposes but also as a valuable input for real-world policymaking. Despite the rapid aging of the Japanese population no statistical survey that could properly capture the diversity of the elderly population from various viewpoints had been carried out in Japan until recently. Against this backdrop RIETI and Hitotsubashi University jointly launched a comprehensive survey of elderly people in 2007 to collect panel data on their lives and health with the University of Tokyo joining from 2009 onward. The data collected in this survey include diverse information on the economic social and health conditions of elderly people. In addition the survey is designed to ensure to the maximum extent possible comparability with preceding surveys such as the Health and Retirement Study (HRS) in the United States the Survey of Health Aging and Retirement in Europe (SHARE) in continental Europe and the English Longitudinal Study of Aging (ELSA) in the United Kingdom. Therefore by analyzing JSTAR data researchers can track the characteristics of the Japanese elderly population in terms of both their specificity and universality in the world. In this sense JSTAR is Japans first-ever globally comparable panel data survey of elderly people.

Korea became an ageing society in 2000 as the proportion of those 65 or older reached 7 of the population. Lacking in basic data on ageing Korea is in need of a structured set of statistical data. Institutional reform and policy-making in preparation against the aged society requires systematic build-up of data that can track individuals labor participation income and asset status spending patterns retirement decisions impact of social welfare health and intra-family transfer of income among others. The purpose of KLoSA is to create the basic data needed to devise and implement effective social economic policies to address the trends that emerge in the process of population ageing. The data will help identify and observe different dimensions of an aged society build datasets that enable studies in different fields and generate data comparable with similar panel studies in other countries (eg. U.S. Europe) that can provide the basis for policy-making and academic studies.

The Lifestyle Interventions and Independence for Elders (LIFE) study was a multicenter, randomized trial that enrolled participants between February 2010 and December 2011, who participated for an average of 2.6 years. Follow-up ended in December 2013. Outcome assessors were blinded to the intervention assignment. Participants were recruited from urban, suburban, and rural communities at 8 centers throughout the United States. We randomized a volunteer sample of 1635 sedentary men and women aged 70 to 89 years who had physical limitations, defined as a score on the Short Physical Performance Battery of 9 or below, but were able to walk 400 m.

Data are lacking on the health social support and economic security of Indias growing elderly population and concern is mounting about the well-being of this expanding group. By assembling a research team of demographers economists medical doctors sociologists and public health and policy experts LASI aims to supply the data needed to take stock of the situation of Indias elderly population. It is hoped that this evidence base will contribute to cross-national studies of aging and will inform the design of policies that can protect and support the growing elderly community.

The Mexican Health and Aging Study (MHAS) started as a prospective panel study of health and aging in Mexico. The MHAS study will design field and disseminate the data to achieve research goals that include: examining the aging processes and its disease and disability burden in a large representative panel of older Mexicans evaluating the effects of individual behaviors early life circumstances migration and economic history community characteristics and family transfer systems on multiple health outcomes comparing the health dynamics of older Mexicans with comparably aged Mexican-born migrants in the U.S. and second generation Mexican-American using similar data from the U.S. population (for example the biennial Health and Retirement Study HRS) to assess the durability of the migrant health advantage assess the health of all components of the population from which migrants are selectively recruited and considering ways in which intergenerational transfer systems affect old-age health dynamics in a country where migration is commonplace and remittances may repay prior investments or ensure against uncertainty in old age.

MIDUS (Midlife in the U.S.) is a national sample of continental U.S. residents aged 25 to 74 who were first interviewed in 1995-96. The original study was conceived by a multidisciplinary team of investigators interested in the influence of psychological and social factors on health broadly defined as people age from early adulthood to later life. MIDUS is a collaborative interdisciplinary investigation of patterns predictors and consequences of midlife development in the areas of physical health psychological well-being and social responsibility. The scientific scope of the study was extended by adding comprehensive biological assessments on a subsample of respondents. In its longitudinal extension MIDUS thus became a forum for investigating health as an integrative process which involved combining the behavioral and social sciences together with bio-medically oriented research. More information

Cross-sectional MRI Data in Young Middle Aged Non-demented and Demented Older Adults: This set consists of a cross-sectional collection of 416 subjects aged 18 to 96. For each subject 3 or 4 individual T1-weighted MRI scans obtained in single scan sessions are included. The subjects are all right-handed and include both men and women. 100 of the included subjects over the age of 60 have been clinically diagnosed with very mild to moderate Alzheimer’s disease (AD). Additionally a reliability data set is included containing 20 non-demented subjects imaged on a subsequent visit within 90 days of their initial session. Longitudinal MRI Data in Non-demented and Demented Older Adults: This set consists of a longitudinal collection of 150 subjects aged 60 to 96. Each subject was scanned on two or more visits separated by at least one year for a total of 373 imaging sessions. For each subject 3 or 4 individual T1-weighted MRI scans obtained in single scan sessions are included. The subjects are all right-handed and include both men and women. 72 of the subjects were characterized as non-demented throughout the study. 64 of the included subjects were characterized as demented at the time of their initial visits and remained so for subsequent scans including 51 individuals with mild to moderate Alzheimer’s disease. Another 14 subjects were characterized as non-demented at the time of their initial visit and were subsequently characterized as demented at a later visit.

MOST is a longitudinal, prospective, observational study of knee osteoarthritis in older Americans with the disease or at increased risk of developing it. The study is comprised of two clinical centers, a data coordinating center, and an analysis center. Beginning in 2003, 3026 individuals aged 50-79 years were enrolled. Approximately 15% of this “Original Cohort” are African Americans and 60% are women. Examinations at baseline, and 15, 30, 60, 72 (telephone interview) and 84 months included assessment of risk factors, OA disease characteristics, physical function and disability, and measures of physical activity, strength, gait and quantitative sensory testing. At each clinical assessment, radiological assessments of OA (x-rays and MRI) were obtained. In 2016-2018 the cohort was enriched by the recruitment of an additional 1,500 “New Cohort” participants with early or mild knee symptoms and x-ray findings of OA. The “New Cohort” and surviving participants without end-stage knee osteoarthritis in the “Original Cohort” were asked to participate in clinic visits and telephone follow-up contacts at 144- ,152- 160- and 168-months. 

The AgingResearchBiobank contains knee radiographs, full limb radiographs, and knee MRIs from the MOST cohort through the 168-month follow-up visit.

The NLTCS was designed to measure disability and the use of long-term care (LTC) among the U.S. elderly (age 65) population at multiple points in time from 1982 to 2004. The cumulative sample size over the six survey years (waves) was 49258 distinct persons all of whom were enrolled in the Medicare program. The NLTCS is a nationally-representative sample that includes both community and institutionalized populations. It is also longitudinal as the sample individuals joined the survey once they reach 65 years of age (except for 1982 where ages above 65 were represented) and remained in the survey until they either died or were lost to follow-up. More information

The purpose of this data collection was to provide an appropriate theoretical and empirical approach to concepts measures and methods in the study of Black Americans. Developed with input from social scientists students and a national advisory panel of Black scholars the survey investigates neighborhood-community integration services crime and community contact the role of religion and the church physical and mental health self-esteem life satisfaction employment the effects of chronic unemployment the effects of race on the job interaction with family and friends racial attitudes race identity group stereotypes and race ideology. Demographic variables include education marital status income employment status occupation and political behavior and affiliation. More information

Characterization of the microbiomes of healthy human subjects at five major body sites. More information

This dataset contains de-identified raw k-space data and DICOM image files of over 1,500 knees, 6,970 brains, 312 prostate exams, 300 clinical breast exams.

Points that represent the locations of housing geared to older adults in Waterloo including independent living assistive supportive living and long-term care homes. Where a property contains more than one level of care multiple points are placed at the same location.

MrOS, a multi-center longitudinal, observational study, was established in 1998. The U.S. clinical sites were located at the University of Alabama at Birmingham; Oregon Health and Science University; Stanford University; University of Minnesota; University of Pittsburgh; and University of California, San Diego. Each site was expected to enroll at least 950 men and the enrollments were required to reflect the race and age demographics of the site’s geographic area. In total, 5,994 U.S. participants were enrolled in MrOS between March 2000 and April 2002. In 2001, the study expanded internationally to collaborate with sites in Hong Kong and Sweden. The Hong Kong site enrolled 2,000 men and the sites in Sweden enrolled approximately 3,000 men. MrOS U.S. study participants had to be men aged 65 and older; ambulatory; live near the clinical site during the study period; able to adhere to study procedures; and had not had bilateral hip replacement or another condition that would prevent or interfere with study participation. After enrollment, participants were required to complete a baseline examination, which included the evaluation of bone mineral density and structure, physical function, quality of life, diet, and medical history. During the follow-up period, questionnaires were used to capture information about the occurrence of back pain, falls, fractures, newly diagnosed prostate cancer and recent prostate biopsies. Participants completed the regular questionnaires every four months and a more extensive questionnaire periodically. At approximately 5-year intervals, participants underwent a comprehensive assessment at the clinic site. Most baseline evaluations were repeated during the comprehensive assessments. Follow-up clinical assessments included detailed measures of sleep health (including overnight polysomnography in ~3000 men), osteoarthritis, and expanded assessment of physical function and performance.

The Panel Study of Income Dynamics – PSID – is the longest running longitudinal household survey in the world. The study began in 1968 with a nationally representative sample of over 18000 individuals living in 5000 families in the United States. Information on these individuals and their descendants has been collected continuously including data covering employment income wealth expenditures health marriage childbearing child development philanthropy education and numerous other topics. The PSID is directed by faculty at the University of Michigan and the data are available on this website without cost to researchers and analysts.

Prevalence and patterns of drug use in the general population (adults or school children) is assessed through surveys based on representative probabilistic samples of the whole population under study. Interview surveys are based on self-report of participants regarding present and past behaviours personal characteristics knowledge and attitudes regarding drugs or other health topics.

Prevalence and patterns of drug use in the general population (adults or school children) is assessed through surveys based on representative probabilistic samples of the whole population under study. Interview surveys are based on self-report of participants regarding present and past behaviours personal characteristics knowledge and attitudes regarding drugs or other health topics.

For a majority of the cases included in the study, inclusion criteria were a neuropathological diagnosis of Progressive Supranuclear Palsy (PSP; n=2,595), with the exception of a small number of cases, both living and deceased, that only had a neurological diagnosis (n=184). PSP subjects with comorbid pathological features of other neurodegenerative disorders were not excluded from the study including AD-like features, Lewy bodies, and TDP-43 as prevalence of these comorbid features. The controls had no clinical evidence of cognitive impairment or a movement disorder (n=5,584) and neuropathologically could only have age-related pathological changes. A full list of the institutions where the material was collected can be found in our full text publication and it should be noted many of the samples included here were contained in previous studies (Höglinger et. al., 2011; Chen et. al, 2018; Sanchez-Contreras et. al., 2018).

The RELATE study compiles cross-national data that contain information that can be used to examine the effects of early life conditions on older adult health conditions including heart disease diabetes obesity functionality mortality and self-reported health. The complete cross sectional/longitudinal dataset (n147278) was compiled from major studies of older adults or households across the world that in most instances are representative of the older adult population either nationally in major urban centers or in provinces. It includes over 180 variables with information on demographic and geographic variables along with information about early life conditions and life course events for older adults in low- middle- and high-income countries. Selected variables were harmonized to facilitate cross national comparisons. In this first public release of the RELATE data a subset of the data (n88273) is being released. The subset includes harmonized data of older adults from the following regions of the world: Africa (Ghana and South Africa) Asia (China India) Latin America (Costa Rica major cities in Latin America) and the United States (Puerto Rico Wisconsin). This first release of the data collection is composed of 19 downloadable parts: Part 1 includes the harmonized cross-national RELATE dataset which harmonizes data from parts 2 through 19. Specifically parts 2 through 19 include data from Costa Rica (Part 2) Puerto Rico (Part 3) the United States (Wisconsin) (Part 4) Argentina (Part 5) Barbados (Part 6) Brazil (Part 7) Chile (Part 8) Cuba (Part 9) Mexico (Parts 10 and 15) Uruguay (Part 11) China (Parts 12 18 and 19) Ghana (Part 13) India (Part 14) Russia (Part 16) and South Africa (Part 17). More information

The REACH study was a multisite caregiver intervention study that compared a variety of interventions for dementia caregivers to control conditions. The study was a landmark in its large sample size use of multiple sites and inclusion of large numbers of White Hispanic and African American caregivers.

The REACH study was a multisite caregiver intervention study that compared a variety of interventions for dementia caregivers to control conditions. The study was a landmark in its large sample size use of multiple sites and inclusion of large numbers of White Hispanic and African American caregivers.

SAGES I was a five-year prospective cohort study that enrolled 560 patients, who were all recruited from two large hospitals in Boston, Massachusetts from 2010 to 2013, with follow-up to 2015. Participants were age 70 years and older, scheduled to undergo major elective surgery with an expected hospital stay of at least two days, and who did not have diagnosed or recognizable dementia. Individuals were excluded from enrollment if dementia, active delirium, or other cognitive impairment were present prior to surgery; other exclusions included hospitalization within three months of study enrollment, terminal illness, or a condition that might confound recognition of delirium (e.g., schizophrenia), or that might preclude completion of follow-up interviews (e.g., cancer requiring intensive chemotherapy). Study participants underwent detailed in-home baseline assessments for physical and cognitive function prior to surgery. During their post-surgery hospital stay, patients were interviewed daily to assess for delirium using the long Confusion Assessment Method (CAM), which enables determination of delirium presence using the CAM algorithm, and measurement of delirium severity using the CAM-S long and short forms. Delirium presence was also ascertained by a validated chart review approach. After hospital discharge, participants completed telephone and in-home assessments to measure cognitive and physical function at predetermined intervals (1,2,6,12, and 18 months post-operatively) during follow-up, which ranged up to 18 months. Additionally, blood-based biomarkers were obtained from participants at four time points—baseline (preoperatively), in the post-anesthesia care unit, on the morning of postoperative day 2, and at one-month following surgery. Clinical data included health habits, hearing/vision impairment, comorbidity, and frailty at baseline. Finally, cognitive reserve markers, including personal educational history and reading level, were obtained.

The SAGES II study was a 5-year prospective observational study of 420 community dwelling persons, aged 65 years and older, assessed prior to scheduled surgery and  daily throughout hospitalization to observe for development of delirium and other clinical outcomes. Delirium is measured with the Confusion Assessment Method (CAM), long form, after cognitive testing. Cognitive function is measured with a detailed neuropsychologic test battery, summarized as a weighted composite, the General Cognitive Performance (GCP) score. Other key measures include cerebrospinal fluid and plasma-based biomarkers, magnetic resonance imaging (MRI), transcranial magnetic stimulation (TMS)/electroencephalography (EEG), and Amyloid positron emission tomography (PET) imaging.  The imaging/neurophysiology procedures were completed on a subset of participants. 

The Study of Osteoporotic Fractures was a multi-site longitudinal study, which was established to assess women aged 65 and older for risk factors for osteoporotic fractures. The study was operational from 1986 until 2017 and had over 10,000 participants. Study participants were recruited from four U.S. cities: Baltimore, MD; Minneapolis, MN; Pittsburgh, PA; and Portland, OR. Initially, only white women were included in the study because they represented the highest risk group for osteoporotic fractures. However, in 1997 the study began to recruit African American women, as well. Women were excluded from participation at baseline if they had bilateral hip prostheses or were unable to walk without the assistance of another person. Study participants attended a series of clinical visits, where they underwent various physical and mental evaluations. The evaluations included imaging to measure bone density, physical examinations, and questionnaires. In addition to the clinical visits, participants were contacted via telephone or mail every four months to complete follow-up assessments, in order to obtain information regarding falls, fractures, and vital status.

Nine individual neuropsychiatric symptom domains (agitation or aggression, anxiety, apathy or indifference, delusions, depression or dysphoria, disinhibition, hallucinations, irritability or lability, nighttime behaviors) measured using the Neuropsychiatric Symptom Inventory Questionnaire were tested for association with single-nucleotide polymorphisms (SNPs) with minor allele frequency > 5% in a sample of 12,806 participants with mild cognitive impairment or dementia.

Participants were sampled from Alzheimer’s Disease Research Centers (ADRCs) throughout the United States and were of European genetic ancestry. For each NPS domain, a participant was classified as a “case” if they experienced the symptom in the month preceding any visit, and as a “control” otherwise. Parallel logistic regressions were performed for each NPS domain while controlling for sex (male v. female), batch (categorical with 15 levels), and the first 10 genetic PCs.

The TTrials were a set of seven interventional clinical trials, which began in 2009 and concluded in 2018. Each had a specific focus: Sexual Function Trial; Physical Function Trial; Vitality Trial; Cognitive Function Trial; Bone Trial; Cardiovascular Trial; and Anemia Trial. A total of 790 participants were enrolled at 12 clinical sites across the United States. Participants were men aged 65 and older who had early morning serum total testosterone concentrations <275 ng/dL. Men were excluded from participation if they had or were at risk of developing a disease or condition that might be worsened by testosterone treatment or would interfere with study procedures and outcomes. Participants were allocated to receive either a testosterone gel or a placebo gel, which they applied once a day for 12 months. In all seven trials, participants underwent specific assessments at predetermined intervals and were monitored for adverse effects of testosterone treatment.

The primary outcome, assessed in a time-to-event analysis, was the first adjudicated serious fall injury, which was defined as a fall resulting in a fracture (other than a thoracic or lumbar vertebral fracture), joint dislocation, or cut requiring closure or a fall resulting in hospitalization for a head injury, sprain or strain, bruising or swelling, or other serious injury. The secondary outcome, assessed in a time-to-event analysis, was the first participant-reported fall injury. Data on fall injuries were collected every 4 months by means of telephone interviews, which were conducted by personnel who were unaware of the treatment assignments. During these interviews, participants were also asked about hospital admissions, emergency department visits, and other health care utilization. A random subsample of 743 participants (384 intervention, 359 control) aged 75 and older were also assessed for concern about falling, anxiety, depression, physical function, and disability at the baseline, 12-month, and 24-month interviews. Serious fall injuries that were reported during telephone interviews were reviewed by an adjudication team that was unaware of the treatment assignments. The events were then verified with the use of administrative claims data (provided by trial sites) or encounter data (provided by the Centers for Medicare and Medicaid Services) or both or by review of electronic health records. Each case was reviewed independently by two physician adjudicators who were unaware of the treatment assignment. Events deemed as “definitely” or “highly likely” to be a serious fall injury on the basis of verification of participant report by at least one additional objective source were adjudicated as events that met the criteria for the primary outcome.

The Study of Women’s Health Across the Nation (SWAN) is a multi-site longitudinal, epidemiologic study designed to examine the health of women during their middle years. The study examines physical, biological, psychological and social changes that occur during this transitional period. The study began in 1994 and is in its twenty-fifth year. Between 1996 and 1997, 3,302 participants joined SWAN through seven designated research centers. The research centers are located in the following communities: Ann Arbor, MI (University of Michigan), Boston, MA (Massachusetts General Hospital), Chicago, IL (Rush University Medical Center), Alameda and Contra Costa County, CA (University of California Davis and Kaiser Permanente in Oakland, CA), Los Angeles, CA (University of California at Los Angeles), Jersey City, NJ (Albert Einstein College of Medicine), and Pittsburgh, PA (University of Pittsburgh). SWAN participants represent five racial/ethnic groups (Black, Chinese, Hispanic, Japanese, and White) and a variety of backgrounds and cultures. The study design was developed using a collaborative process. SWAN consisted of a cross-sectional study and a longitudinal cohort study, both of which employed common protocols across the seven research centers. Focus groups were conducted to inform the development of the study design and the protocols and to ensure the relevance and the appropriateness of the protocols to the multiethnic cohort.

STARRRS provides an open databank of longitudinal phenotypic data, neuroimaging scans, and tissue and other biological samples for distribution, utilizing a validated Long Evans rat model that features reliable individual differences in neurocognitive outcome with advanced age.

Male and female rats are followed from youth to old age with state-of-the-art technologies to assess brain structure and function non-invasively and with dynamic phenotypic measurements. The resource is intended to remain flexible in design over time and stakeholder community input is highly encouraged.

This research measures awareness access use of and attitudes towards fixed and mobile telecoms internet multi-channel TV and radio among UK adults (aged 16). Across the UK overall and within each UK nation the Technology Tracker provides detailed analysis by key population demographics sub-region and by urban vs. rural. It collects data that enable comparisons to be made with older data collected by Ofcom informing Ofcom analysis reports and decisions. More information

The Vietnam Era Twin Study of Aging (VETSA) is a large-scale investigation of cognitive aging from middle to later age. The intended sample was recruited from the Vietnam Era Twin Registry (VETR) a registry of middle-aged male-male twin pairs who both served in the United States military during the Vietnam conflict (1965-1975). VETSA employs a multitrait multimethod approach to cognitive assessment to focus on the genetic and environmental contributions to cognitive processes over time as well as the relative contributions to cognitive aging from health social personality and other contextual factors.

The FRA survey on violence against women is based on face-to-face interviews with 42000 women across the EU. The survey was carried out between March and September 2012 and presents the most comprehensive survey worldwide on womens experiences of violence. The survey asked women about their experiences of physical sexual and psychological violence including domestic violence since the age of 15 and over the 12 months before the interview. Questions were also asked about incidents of stalking sexual harassment and the role played by new technologies in womens experiences of abuse. In addition the survey asked about respondents experiences of violence in childhood.

This dataset contains GWAS summary statistics derived from single-variant association tests for WGS data (minor allele count ≥ 10, call rate > 0.95) from 3,540 Koreans aged 60 years or older (1,583 AD cases, 1,957 controls). SNP array data (minor allele frequency > 0.01, call rate > 0.95) was derived from 2,978 Japanese aged 65 years or older (1,336 AD cases, 1,642 controls). There are five Korean WGS GWAS result datasets (the total Korean sample, APOE ε4 carriers, APOE ε4 non-carriers, males, and females) and five meta-analyzed GWAS result datasets (the total Korean and Japanese sample, APOE ε4 carriers, APOE ε4 non-carriers, males, and females). We do not provide GWAS results derived from Japanese datasets only.