Bioprinted 3D in-vitro models to determine mechanisms of cognitive benefits of exercise in the elderly

Exercise can delay or prevent age-related cognitive decline through the release of certain hormones from skeletal muscles, bone and liver into the circulation that are taken up in the brain, and by extending neuroprotective effects. This research program will study the hormones released and their immediate effect on neighboring neurons. Understanding which released hormones promote neuronal health and connectivity will allow the design of exercise protocols suitable for older adults that maximize the release of the most efficacious hormones. It will also allow for the design of pharmaceuticals to provide the same neuroprotective effects for those who cannot exercise, due to frailty, disease, or injury.

“This funding has been critical in establishing important interdisciplinary collaborations. We have followed this seed funding and have applied for a new Frontiers grant based on this research theme and with an expanded team of international investigators. The seed funding has established aging-related research as a core vector in my research portfolio.” — P. Ravi Selvaganapathy