Enhancing the quality of life for older adults with end-stage knee osteoarthritis through patient phenotyping to tailor the clinical management

Worldwide, knee osteoarthritis (KOA) is one of the largest contributors to disability in older adults. End-stage treatment for KOA is total knee arthroplasty surgery; however, up to 30 percent of patients continue to have significant pain and disability after surgery. Patients presenting with end-stage KOA vary considerably in clinical and structural presentation. Despite this variability, clinical management and perioperative rehabilitation lack the consistency and evidence to incorporate patient-specific factors. This project aims to identify phenotypes of patients with end-stage KOA who would benefit from targeted management of rehabilitation, and clinical and surgical decision-making, in order to improve patient quality of life and reduce the societal, and economic burden.